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A click chemistry approach identifies target proteins of xanthohumol

Brodziak-Jarosz, Lidia, Fujikawa, Yuuta, Pastor-Flores, Daniel, Kasikci, Sonay, Jirásek, Petr, Pitzl, Sebastian, Owen, Robert W., Klika, Karel D., Gerhäuser, Clarissa, Amslinger, Sabine and Dick, Tobias P. (2016) A click chemistry approach identifies target proteins of xanthohumol. Molecular Nutrition & Food Research 60 (4), pp. 737-748.

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Other URL: http://doi.org/10.1002/mnfr.201500613


Abstract

Scope Many phytochemicals with beneficial pharmacological properties contain electrophilic sites, e.g. α,β-unsaturated carbonyl (enone) groups. There is increasing evidence that many biological effects of electrophilic compounds depend on covalent conjugation to reactive protein thiols. For example, the reaction of electrophiles with cysteinyl residues of the sensor protein Keap1 activates the ...

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Item type:Article
Date:2016
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Identification Number:
ValueType
10.1002/mnfr.201500613DOI
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35007
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