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A click chemistry approach identifies target proteins of xanthohumol

Brodziak-Jarosz, Lidia ; Fujikawa, Yuuta ; Pastor-Flores, Daniel ; Kasikci, Sonay ; Jirásek, Petr ; Pitzl, Sebastian ; Owen, Robert W. ; Klika, Karel D. ; Gerhäuser, Clarissa ; Amslinger, Sabine ; Dick, Tobias P.



Abstract

ScopeMany phytochemicals with beneficial pharmacological properties contain electrophilic sites, e.g. ,-unsaturated carbonyl (enone) groups. There is increasing evidence that many biological effects of electrophilic compounds depend on covalent conjugation to reactive protein thiols. For example, the reaction of electrophiles with cysteinyl residues of the sensor protein Keap1 activates the ...

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