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Inhibition of interleukin-3- and interferon- α-induced JAK/STAT signaling by the synthetic α-X-2′,3,4,4′-tetramethoxychalcones α-Br-TMC and α-CF3-TMC

Jobst, Belinda ; Weigl, Julia ; Michl, Carina ; Vivarelli, Fabio ; Pinz, Sophia ; Amslinger, Sabine ; Rascle, Anne


The JAK/STAT pathway is an essential mediator of cytokine signaling, often upregulated in human diseases and therefore recognized as a relevant therapeutic target. We previously identified the synthetic chalcone-alpha-bromo-2',3,4,4'-tetramethoxychalcone (alpha-Br-TMC) as a novel JAK2/STAT5 inhibitor. We also found that treatment with alpha-Br-TMC resulted in a downward shift of STAT5 proteins in ...


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