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Inhibition of interleukin-3- and interferon- α-induced JAK/STAT signaling by the synthetic α-X-2′,3,4,4′-tetramethoxychalcones α-Br-TMC and α-CF3-TMC

Jobst, Belinda, Weigl, Julia, Michl, Carina, Vivarelli, Fabio, Pinz, Sophia, Amslinger, Sabine and Rascle, Anne (2016) Inhibition of interleukin-3- and interferon- α-induced JAK/STAT signaling by the synthetic α-X-2′,3,4,4′-tetramethoxychalcones α-Br-TMC and α-CF3-TMC. Biological Chemistry 397 (11), pp. 1187-1204.

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Other URL: http://doi.org/10.1515/hsz-2016-0148


Abstract

The JAK/STAT pathway is an essential mediator of cytokine signaling, often upregulated in human diseases and therefore recognized as a relevant therapeutic target. We previously identified the synthetic chalcone α-bromo-2′,3,4,4′-tetramethoxychalcone (α-Br-TMC) as a novel JAK2/STAT5 inhibitor. We also found that treatment with α-Br-TMC resulted in a downward shift of STAT5 proteins in SDS-PAGE, ...

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Item type:Article
Date:2016
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Identification Number:
ValueType
10.1515/hsz-2016-0148DOI
Keywords:chalcone; cysteine; gene expression; mutagenesis; phosphorylation; STAT1/2/5
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35009
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