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ABCG2/BCRP: Specific and Nonspecific Modulators

Peña-Solórzano, Diana, Stark, Simone Alexandra, König, Burkhard , Sierra, Cesar Augusto and Ochoa-Puentes, Cristian (2017) ABCG2/BCRP: Specific and Nonspecific Modulators. Medicinal Research Reviews 5, pp. 987-1050.

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Abstract

Multidrug resistance (MDR) in cancer cells is the development of resistance to a variety of structurally and functionally nonrelated anticancer drugs. This phenomenon has become a major obstacle to cancer chemotherapy seriously affecting the clinical outcome. MDR is associated with increased drug efflux from cells mediated by an energy-dependent mechanism involving the ATP-binding cassette (ABC) ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Identification Number:
ValueType
10.1002/med.21428DOI
Keywords:CANCER RESISTANCE PROTEIN; P-GLYCOPROTEIN ABCB1; REVERSES MULTIDRUG-RESISTANCE; TYROSINE KINASE INHIBITOR; MEDIATED DRUG-RESISTANCE; TRANSPORTER IN-VITRO; STEM-LIKE CELLS; G MEMBER 2; MARINE NATURAL-PRODUCTS; SELECTIVE INHIBITORS; ABC transporter; ABCG2/BCRP; multidrug resistance; ABC inhibitor; ABC modulator
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35083
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