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ABCG2/BCRP: Specific and Nonspecific Modulators

Peña-Solórzano, Diana ; Stark, Simone Alexandra ; König, Burkhard ; Sierra, Cesar Augusto ; Ochoa-Puentes, Cristian



Zusammenfassung

Multidrug resistance (MDR) in cancer cells is the development of resistance to a variety of structurally and functionally nonrelated anticancer drugs. This phenomenon has become a major obstacle to cancer chemotherapy seriously affecting the clinical outcome. MDR is associated with increased drug efflux from cells mediated by an energy-dependent mechanism involving the ATP-binding cassette (ABC) ...

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