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Distinct Genetic Risk Profile of the Rapidly Progressing Diffuse-Trickling Subtype of Geographic Atrophy in Age-Related Macular Degeneration (AMD)

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Fleckenstein, Monika ; Grassmann, Felix ; Lindner, Moritz ; Pfau, Maximilian ; Czauderna, Joanna ; Strunz, Tobias ; von Strachwitz, Claudia ; Schmitz-Valckenberg, Steffen ; Holz, Frank G. ; Weber, Bernhard H. F.
Date of publication of this fulltext: 30 Jan 2017 13:46


PURPOSE. To genetically characterize a subphenotype of geographic atrophy (GA) in AMD associated with rapid progression and a diffuse-trickling appearance on fundus autofluorescence imaging. METHODS. Patients from the Fundus Autofluorescence in Age-Related Macular Degeneration Study were phenotyped for diffuse-trickling GA (dt-GA; n = 44). DNA was analyzed for 10 known AMD-associated genetic ...


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