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Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells

Milenkovic, Andrea, Brandl, C., Milenkovic, Vladimir M., Jendryke, T., Sirianant, L., Wanitchakool, P., Zimmermann, S. and Weber, Bernhard H. F. (2015) Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells. Proc Natl Acad Sci U S A (PNAS) 112 (20), E2630-E2639.

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Abstract

In response to cell swelling, volume-regulated anion channels (VRACs) participate in a process known as regulatory volume decrease (RVD). Only recently, first insight into the molecular identity of mammalian VRACs was obtained by the discovery of the leucine-rich repeats containing 8A (LRRC8A) gene. Here, we show that bestrophin 1 (BEST1) but not LRRC8A is crucial for volume regulation in human ...

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Item type:Article
Date:2015
Institutions:Medicine > Lehrstuhl für Augenheilkunde
Medicine > Lehrstuhl für Humangenetik
Medicine > Lehrstuhl für Psychiatrie und Psychotherapie > Molekulare Neurowissenscahften
Biology, Preclinical Medicine > Institut für Physiologie
Identification Number:
ValueType
10.1073/pnas.1418840112DOI
25941382PubMed ID
Keywords:bestrophin 1; induced pluripotent stem cell; mouse sperm; retinal pigment epithelium; volume-regulated anion channel
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35137
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