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Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells

Milenkovic, Andrea ; Brandl, C. ; Milenkovic, Vladimir M. ; Jendryke, T. ; Sirianant, L. ; Wanitchakool, P. ; Zimmermann, S. ; Weber, Bernhard H. F.



Abstract

In response to cell swelling, volume-regulated anion channels (VRACs) participate in a process known as regulatory volume decrease (RVD). Only recently, first insight into the molecular identity of mammalian VRACs was obtained by the discovery of the leucine-rich repeats containing 8A (LRRC8A) gene. Here, we show that bestrophin 1 (BEST1) but not LRRC8A is crucial for volume regulation in human ...

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