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Multi-systemic Langerhans cell Histiocytosis in an adult

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Hegemann, Marie-Valerie ; Schreml, Stephan
Date of publication of this fulltext: 21 Apr 2017 10:22


The etiology of Langerhans cell histiocytosis (LCH), a mix between immune dysregulation, inflammation, and malignancy, remains unclear.1; 2; 3 ; 4 In half of the patients, an oncogenic BRAF mutation is found. 3 Because of the diversity of symptoms, the diagnosis of LCH, as defined by the Histiocyte Society, is often made with considerable delay. Multisystemic LCH, affecting 2 or more organ ...


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