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Spontaneous immortalization of neural crest-derived corneal progenitor cells after chromosomal aberration

Brandl, C. ; Kaesbauer, J. ; Weber, Bernhard H. F. ; Morsczeck, C.


OBJECTIVES: In a previous study, we have reported the existence of neural crest-derived stem cell-like cells originating from the corneal limbus of juvenile mice (termed murine corneal cells, MCCs). To yield a sufficient number of MCCs, for example, for cell-therapy approaches, here we have investigated MCCs' ability for extensive proliferation, and we have evaluated their stem cell qualities and ...


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