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Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration

Ebert, Stefanie ; Weigelt, K. ; Walczak, Yana ; Drobnik, W. ; Mauerer, Richard ; Hume, David A. ; Weber, Bernhard H. F.



Abstract

Microgliosis is a common phenomenon in neurodegenerative disorders including retinal dystrophies. We performed a detailed characterization of activated microglia in the retinoschisin (Rs1h)-deficient (Rs1h(-/Y)) mouse model of inherited retinal degeneration. To visualize and isolate microglia, we crossed Rs1h(-/Y) animals with transgenic MacGreen mice, which express green fluorescent protein ...

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