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Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene

Fritsche, L. G. ; Freitag-Wolf, S. ; Bettecken, T. ; Meitinger, T. ; Keilhauer, C. N. ; Krawczak, Michael ; Weber, Bernhard H. F.


Age-related macular degeneration (AMD) is a frequent, multifactorial disease of the central retina and a major cause of irreversible vision loss in industrialized countries. Apolipoprotein E (APOE) has been consistently associated with AMD, particularly its two functional isoforms E2 (predisposing) and E4 (protective). The biological correlate of this association, however, is still unclear. In ...


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