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Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene

Fritsche, L. G., Freitag-Wolf, S., Bettecken, T., Meitinger, T., Keilhauer, C. N., Krawczak, Michael and Weber, Bernhard H. F. (2009) Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene. Human Mutation 30, pp. 1048-1053.

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Abstract

Age-related macular degeneration (AMD) is a frequent, multifactorial disease of the central retina and a major cause of irreversible vision loss in industrialized countries. Apolipoprotein E (APOE) has been consistently associated with AMD, particularly its two functional isoforms E2 (predisposing) and E4 (protective). The biological correlate of this association, however, is still unclear. In ...

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Item type:Article
Date:2009
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1002/humu.20957DOI
19466957PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35207
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