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Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk

Rivera, A. ; Fisher, Sheila A. ; Fritsche, L. G. ; Keilhauer, Claudia N. ; Lichtner, Peter ; Meitinger, Thomas ; Weber, Bernhard H. F.



Abstract

Age-related macular degeneration (AMD) is a multifactorial disease and a prevalent cause of visual impairment in developed countries. Risk factors include environmental components and genetic determinants. The complement factor H (CFH) has been the first major susceptibility gene for AMD identified within 1q32. Here, we focused on a second region of interest in 10q26 where a recent meta-analysis ...

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