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Effect of Late-stage Therapy on Disease Progression in AAV-mediated Rescue of Photoreceptor Cells in the Retinoschisin-deficient Mouse

Janssen, A., Min, S. H., Molday, L. ., Tanimoto, N., Seeliger, N. W., Hauswirth, W. W., Molday, R. S. and Weber, Bernhard H. F. (2008) Effect of Late-stage Therapy on Disease Progression in AAV-mediated Rescue of Photoreceptor Cells in the Retinoschisin-deficient Mouse. Molecular Therapy 16, pp. 1010-1017.

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Abstract

Proof-of-concept for a successful adeno-associated virus serotype 5 (AAV5)-mediated gene therapy in X-linked juvenile retinoschisis (XLRS) has been demonstrated in an established mouse model for this condition. The initial studies concentrated on early time-points of treatment. In this study, we aimed to explore the consequences of single subretinal injections administered at various stages of ...

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Item type:Article
Date:2008
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1038/mt.2008.57DOI
18388913PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35222
Owner only: item control page

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