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Dap12 expression in activated microglia from retinoschisin-deficient retina and its PU.1-dependent promoter regulation

Weigelt, K. ; Ernst, W. ; Walczak, Yana ; Ebert, Stefanie ; Loenhardt, T. ; Klug, Maja ; Rehli, Michael ; Weber, Bernhard H. F.



Zusammenfassung

Several alterations in the expression of immune-related transcripts were identified recently in the degenerating retina of the retinoschisin knockout (Rs1h(-/Y)) mouse, including the strong expression of the adaptor protein Dap12. As Dap12 is found in leukocytes, we hypothesized that its disease-related expression may be confined to activated retinal microglia cells. To test this hypothesis, we ...

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