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Dap12 expression in activated microglia from retinoschisin-deficient retina and its PU.1-dependent promoter regulation

Weigelt, K., Ernst, W., Walczak, Yana, Ebert, Stefanie, Loenhardt, T., Klug, Maja, Rehli, Michael and Weber, Bernhard H. F. (2007) Dap12 expression in activated microglia from retinoschisin-deficient retina and its PU.1-dependent promoter regulation. Journal of Leukocyte Biology (JLB) 82, pp. 1564-1574.

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Abstract

Several alterations in the expression of immune-related transcripts were identified recently in the degenerating retina of the retinoschisin knockout (Rs1h(-/Y)) mouse, including the strong expression of the adaptor protein Dap12. As Dap12 is found in leukocytes, we hypothesized that its disease-related expression may be confined to activated retinal microglia cells. To test this hypothesis, we ...

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Item type:Article
Date:2007
Institutions:Medicine > Lehrstuhl für Humangenetik
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
10.1189/jlb.0707447DOI
17827340PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35227
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