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Genetic analysis of candidate genes modifying the age-at-onset in Huntington’s disease

Metzger, S, Bauer, P, Tomiuk, J, Laccone, F, Weber, Bernhard H. F. , DiDonato, S, Gellera, C, Mariotti, C, Lange, H W, Weirich-Schwaiger, H, Wenning, G K, Seppi, K, Melegh, B, Havasi, V, Balikó, L, Wieczorek, S and et. all, . (2006) Genetic analysis of candidate genes modifying the age-at-onset in Huntington’s disease. Human Genetics 120 (2), pp. 285-292.

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Abstract

The expansion of a polymorphic CAG repeat in the HD gene encoding huntingtin has been identified as the major cause of Huntington’s disease (HD) and determines 42–73% of the variance in the age-at-onset of the disease. Polymorphisms in huntingtin interacting or associated genes are thought to modify the course of the disease. To identify genetic modifiers influencing the age at disease onset, we ...

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Item type:Article
Date:September 2006
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1007/s00439-006-0221-2DOI
Keywords:Huntington’s disease, Age-at-onset, Genetic modifiers, Association study
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35275
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