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Comparative mapping of human claudin-1 (CLDN1) in great apes

Nanda, I. ; Krämer, F. ; Weber, Bernhard H. F. ; Schempp, W. ; Schmid, M.


The gene encoding claudin-1 (CLDN1) has been mapped to human chromosome 3 (HSA3; 3q28→q29) using a radiation hybrid panel. Employing fluorescence in situ hybridization (FISH) we here show that a human P1-derived artificial chromosome (PAC) containing CLDN1 detects the orthologous sites in chromosomes of the great apes, chimpanzee, gorilla, and orangutan. Furthermore, the chromosomal position of ...


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