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Isolation and characterization of new highly polymorphic DNA markers from the Huntington disease region

Weber, Bernhard H. F. ; Hedrick, A. ; Andrew, S. ; Riess, O. ; Collins, C. ; Kowbel, D. ; Hayden, M.



Abstract

The defect causing Huntington disease (HD) has been mapped to 4p16.3, distal to the DNA marker D4S10. Subsequently, additional polymorphic markers closer to the HD gene have been isolated, which has led to the establishment of predictive testing programs for individuals at risk for HD. Approximately 17% of persons presenting to the Canadian collaborative study for predictive testing for HD have ...

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