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Heterozygous NTF4 Mutations Impairing Neurotrophin-4 Signaling in Patients with Primary Open-Angle Glaucoma

Pasutto, F. ; Matsumoto, T. ; Mardin, C. Y. ; Sticht, H. ; Brandstätter, J. H. ; Michels-Rautenstrauss, K. ; Weisschuh, N. ; Gramer, E. ; Ramdas, W. D. ; van Koolwijk, L. M. ; Klaver, C. C. ; Vingerling, J. R. ; Weber, Bernhard H. F. ; Kruse, F. E. ; Rautenstrauss, B. ; Barde, Y.-A. ; Reis, A.



Abstract

Glaucoma, a main cause of blindness in the developed world, is characterized by progressive degeneration of retinal ganglion cells (RGCs), resulting in irreversible loss of vision. Although members of the neurotrophin gene family in various species are known to support the survival of numerous neuronal populations, including RGCs, it is less clear whether they are also required for survival and ...

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