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Chromosomal Localization of the Carcinoembryonic Antigen Gene Family and Differential Expression in Various Tumors

Zimmermann, W. ; Weber, Bernhard H. F. ; Ortlieb, B. ; Rudert, F. ; Schempp, W. ; Fiebig, H.-H. ; Shively, J. E. ; von Kleist, S. ; Thompson, J. A.



Abstract

Carcinoembryonic antigen (CEA) is a glycoprotein which is important as a tumor marker for a number of human cancers. It is a member of a gene family comprising about 10 closely related genes. In order to characterize mRNAs transcribed from individual genes we have identified by DNA and RNA hybridization experiments, gene-specific sequences from the 3′ noncoding regions of CEA, and of nonspecific ...

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