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Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer

Kast, K, Rhiem, K, Wappenschmidt, B, Hahnen, E, Hauke, J, Bluemcke, B, Zarghooni, V, Herold, N, Ditsch, N, Kiechle, M, Braun, M, Fischer, C, Dikow, N, Schott, S, Rahner, N, Niederacher, D, Fehm, T, Gehrig, A, Mueller-Reible, C, Arnold, N, Maass, N, Borck, G, de Gregorio, N, Scholz, C, Auber, B, Varon-Manteeva, R, Speiser, D, Horvath, J, Lichey, N, Wimberger, P, Stark, S, Faust, U, Weber, Bernhard H. F. , Emons, G, Zachariae, S, Meindl, A, Schmutzler, R K, Engel, C and German Consortium for Hereditary Breast and Ovarian Cancer, (GC-HBOC) (2016) Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer. Journal of Medical Genetics 53 (7), pp. 465-471.

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Abstract

Purpose To characterise the prevalence of pathogenic germline mutations in BRCA1 and BRCA2 in families with breast cancer (BC) and ovarian cancer (OC) history. Patients and methods Data from 21 401 families were gathered between 1996 and 2014 in a clinical setting in the German Consortium for Hereditary Breast and Ovarian Cancer, comprising full pedigrees with cancer status of all individual ...

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Item type:Article
Date:2016
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1136/jmedgenet-2015-103672DOI
26928436PubMed ID
Keywords:BRCA1; BRCA2; Mutation prevalences; risk criteria
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35344
Owner only: item control page
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