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Identification of multiple CpG-islands and associated conserved sequences in a candidate region for the Huntington Disease gene

Weber, Bernhard H. F. ; Collins, C. ; Kowbel, D. ; Riess, O. ; Hayden, M. R.


The HD locus has been assigned to 4p16.3 distal to the DNA segment D4S10. However, the precise location of this gene is still unknown. At least three regions, together encompassing more than 3.5 Mb of DNA, can still be considered as candidate regions for the HD gene. Our efforts are directed toward the cloning and the complete characterization of one of these regions. Thus far we have cloned 460 ...


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