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The human β-subunit of rod photoreceptor cGMP phosphodiesterase: Complete retinal cDNA sequence and evidence for expression in brain

Collins, C. ; Hutchinson, G. ; Kowbel, D. ; Riess, O. ; Weber, Bernhard H. F. ; Hayden, M. R.


We have identified and sequenced cDNA clones that encode for the human β-subunit of rod cGMP phosphodiesterase (PDEB). A single 2565-bp open reading frame that codes for an 854-amino-acid protein was identified. The human β-subunit protein is 90% identical to the bovine β-subunit and 91% identical to the mouse protein. Northern blot analysis indicates that the gene is expressed as an abundant ...


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