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Exclusion of DNA changes in the bold beta−subunit of the c−GMP phosphodiesterase gene as the cause for Huntington's disease

Riess, O. ; Noerremoelle, A. ; Collins, C. ; Mah, D. ; Weber, Bernhard H. F. ; Hayden, M. R.



Abstract

To identify expressed sequences within candidate regions for the Huntington's disease (HD) gene in 4p16.3, we isolated the gene encoding the beta subunit of the human cGMP phosphodiesterase (PDEB). We formally assessed this as a candidate gene for HD based on it's expression in brain, the demonstration of linkage disequilibrium between intragenic DNA markers and HD, and the demonstration that ...

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