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Delineation of a 50 kilobase DNA segment containing the recombination site in a sporadic case of Huntington's disease

Weber, Bernhard H. F. ; Riess, O. ; Wolff, G. ; Andrew, S. ; Collins, C. ; Graham, R. ; Theilman, J. ; Hayden, M. R.



Abstract

No detectable rearrangements involving chromosome 4p16.3 have been observed in patients with Huntington's disease (HD). New mutations for HD could involve structural alterations which might aid the localization of the defective gene. We have reinvestigated a well documented sporadic case of HD. DNA haplotyping with markers between D4S10 and the telomeric locus D4S141 reveals a recombination event ...

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