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Meta-analysis of genome scans of age-related macular degeneration

Fisher, S. A. ; Abecasis, G. R. ; Yashar, B. M. ; Zareparsi, S. ; Swaroop, A. ; Iyengar, S. K. ; Klein, B. E. ; Klein, R. ; Lee, K. E. ; Majewski, J. ; Schultz, D. W. ; Klein, M. L. ; Seddon, J. M. ; Santangelo, S. L. ; Weeks, D. E. ; Conley, Y. P. ; Mah, T. S. ; Schmidt, S. ; Weber, Bernhard H. F. ; et al, .


A genetic contribution to the development of age-related macular degeneration (AMD) is well established. Several genome-wide linkage studies have identified a number of putative susceptibility loci for AMD but only a few of these regions have been replicated in independent studies. Here, we perform a meta-analysis of six AMD genome screens using the genome-scan meta-analysis method, which allows ...


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