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Evidence of association of APOE with age-related macular degeneration - a pooled analysis of 15 studies

McKay, G. J. ; Patterson, C. C. ; Chakravarthy, U. ; Dasari, S. ; Klaver, C. C. ; Vingerling, J. R. ; Ho, L. ; de Jong, P. T. ; Fletcher, A. E. ; Young, I. S. ; Seland, J. H. ; Rahu, M. ; Soubrane, G. ; Tomazzoli, L. ; Topouzis, F. ; Vioque, J. ; Weber, Bernhard H. F. ; et al, .



Abstract

Age-related macular degeneration (AMD) is the most common cause of incurable visual impairment in high-income countries. Previous studies report inconsistent associations between AMD and apolipoprotein E (APOE), a lipid transport protein involved in low-density cholesterol modulation. Potential interaction between APOE and sex, and smoking status has been reported. We present a pooled analysis (n ...

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