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Isolation of a Drosophila T-box gene closely related to human TBX1

Porsch, M. ; Hofmeyer, K. ; Bausenwein, B. ; Grimm, S. ; Weber, Bernhard H. F. ; Miassod, R. ; Pflugfelder, G. O.



Zusammenfassung

T-box genes, in all metazoans studied from nematode to man, exist in small gene families. They encode transcription factors with a novel, large, and highly conserved DNA binding domain termed the T-domain. In all cases studied, T-box genes have important developmental roles. Two familial diseases, Holt–Oram syndrome and ulnar-mammary syndrome, were recently shown to be caused by mutations in the ...

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