Wege, Anja K., Weber, Florian, Kroemer, Alexander, Ortmann, Olaf, Nimmerjahn, Falk and Brockhoff, Gero (2016) IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM). Oncotarget 8 (2), pp. 2731-2744.
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Abstract
Cancer immunotherapy has been shown to enhance established treatment regimens. We evaluated the potential reinforcing effect of IL-15 in trastuzumab treated humanized tumor mice (HTM) which were generated by concurrent transplantation of neonatal NOD-scid IL2R.null mice with human hematopoietic stem cells (HSC) and HER2 positive breast cancer cells (metastasizing SK-BR-3, solid tumor forming ...
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 7 November 2016 | ||||
| Institutions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) | ||||
| Projects: | Open Access Publizieren (DFG) | ||||
| Identification Number: |
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| Keywords: | NATURAL-KILLER-CELL; C-RECEPTOR POLYMORPHISMS; FC-GAMMA RIIIA; IN-VIVO; T-CELLS; OVEREXPRESSING HER2; GENE POLYMORPHISMS; NK CELLS; ANTIBODY; THERAPY; humanized tumor mice (HTM); trastuzumab; IL-15; immunomodulation; breast cancer | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 35544 |
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