IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM)

URN to cite this document:: urn:nbn:de:bvb:355-epub-355444
DOI to cite this document:: 10.5283/epub.35544

Wege, Anja K. ; Weber, Florian ; Kroemer, Alexander ; Ortmann, Olaf ; Nimmerjahn, Falk ; Brockhoff, Gero

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Date of publication of this fulltext: 07 Apr 2017 08:57

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Abstract

Cancer immunotherapy has been shown to enhance established treatment regimens. We evaluated the potential reinforcing effect of IL-15 in trastuzumab treated humanized tumor mice (HTM) which were generated by concurrent transplantation of neonatal NOD-scid IL2R.null mice with human hematopoietic stem cells (HSC) and HER2 positive breast cancer cells (metastasizing SK-BR-3, solid tumor forming ...