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IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM)

Wege, Anja K., Weber, Florian, Kroemer, Alexander, Ortmann, Olaf, Nimmerjahn, Falk and Brockhoff, Gero (2016) IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM). Oncotarget 8 (2), pp. 2731-2744.

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Date of publication of this fulltext: 07 Apr 2017 08:57

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Other URL: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=13159


Abstract

Cancer immunotherapy has been shown to enhance established treatment regimens. We evaluated the potential reinforcing effect of IL-15 in trastuzumab treated humanized tumor mice (HTM) which were generated by concurrent transplantation of neonatal NOD-scid IL2R.null mice with human hematopoietic stem cells (HSC) and HER2 positive breast cancer cells (metastasizing SK-BR-3, solid tumor forming ...

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Item type:Article
Date:7 November 2016
Institutions:Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe)
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.18632/oncotarget.13159DOI
Keywords:NATURAL-KILLER-CELL; C-RECEPTOR POLYMORPHISMS; FC-GAMMA RIIIA; IN-VIVO; T-CELLS; OVEREXPRESSING HER2; GENE POLYMORPHISMS; NK CELLS; ANTIBODY; THERAPY; humanized tumor mice (HTM); trastuzumab; IL-15; immunomodulation; breast cancer
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35544
Owner only: item control page

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