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Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits

Weber, Bernhard H. F. , Grassmann, Felix, Kiel, Christina, Zimmermann, Martina E., Gorski, Mathias , Grassmann, Veronika, Stark, Klaus and Heid, Iris M. (2017) Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits. Genome Medicine 9 (29), pp. 1-13.

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Date of publication of this fulltext: 21 Apr 2017 13:04

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Other URL: https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0418-0

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

Background: Age-related macular degeneration (AMD) is a common condition of vision loss with disease development strongly influenced by environmental and genetic factors. Recently, 34 loci were associated with AMD at genome-wide significance. So far, little is known about a genetic overlap between AMD and other complex diseases or disease-relevant traits. Methods: For each of 60 complex ...

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Item type:Article
Date:27 March 2017
Institutions:Medicine > Lehrstuhl für Humangenetik
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s13073-017-0418-0DOI
Keywords:GENOME-WIDE ASSOCIATION; PROSTATE-CANCER SUSCEPTIBILITY; CHRONIC KIDNEY-DISEASE; OPEN-ANGLE GLAUCOMA; RHEUMATOID-ARTHRITIS; RISK LOCI; JAPANESE POPULATION; MULTIPLE LOCI; CARDIOVASCULAR-DISEASE; MELANOMA RISK; Age-related macular degeneration; AMD; Genetic risk scores; GRS; Genetic association studies; Complex traits; Shared genetics
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35571
Owner only: item control page

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