ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) does not affect proliferation, apoptosis, or angiogenesis as compared to standard liver resection for colorectal liver metastases

URN to cite this document:

urn:nbn:de:bvb:355-epub-355783 Copy

DOI to cite this document:

10.5283/epub.35578 Copy

Lang, Sven A. ; Joechele, Katharina ; Moser, Christian ; Ruemmele, Petra ; Schmidt, Katharina Maria ; Werner, Jens M. ; Geissler, Edward K. ; Schlitt, Hans J.

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Date of publication of this fulltext: 21 Apr 2017 15:17

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Details

Item type:	Article
Open Access Type:	Gold (with APC)
Höhe Gebühr (aus OpenAPC):	2003.96
Institution der Zahlung:	Regensburg U
Journal or Publication Title:	World Journal of Surgical Oncology
Publisher:	BMC
Place of Publication:	LONDON
Volume:	15
Number of Issue or Book Chapter:	57
Page Range:	pp. 1-8
Date:	7 March 2017
Institutions:	Medicine > Lehrstuhl für Chirurgie
Projects (Historical):	Open Access Publizieren (DFG)
Identification Number:	Value Type 10.1186/s12957-017-1121-8 DOI
Keywords:	EXTENDED-RIGHT HEPATECTOMIES; TUMOR-GROWTH; 2-STAGE HEPATECTOMY; HEPATIC RESECTION; EMBOLIZATION; SURVIVAL; RESECTABILITY; REMNANT; CANCER; METAANALYSIS; Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS); Colorectal liver metastases (CRLM); Apoptosis; Proliferation; Vascularization
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	35578

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Abstract

Background: ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) is a novel two-stage strategy to induce rapid hypertrophy of the future liver remnant (FLR) when patients are in danger of postoperative liver failure due to insufficient FLR. However, the effects of ALPPS on colorectal liver metastases (CRLM) are not clear so far. The aim of our study was to determine ...

Abstract

Background: ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) is a novel two-stage strategy to induce rapid hypertrophy of the future liver remnant (FLR) when patients are in danger of postoperative liver failure due to insufficient FLR. However, the effects of ALPPS on colorectal liver metastases (CRLM) are not clear so far. The aim of our study was to determine whether ALPPS induces proliferation, apoptosis, or vascularization compared to standard (one-stage) liver resection. Methods: Six patients who underwent ALPPS were matched with 12 patients undergoing standard liver resection regarding characteristics of the metastases (size, number), time of appearance (syn-/metachronous), preoperative chemotherapy, primary tumor (localization, TNM stage, grading), and patient variables (gender, age). The largest resected metastasis was used for the analyses. Tissue was stained for tumor cell proliferation (Ki67), apoptosis (TUNEL, caspase-3), vascularization (CD31), and pericytes (alpha SMA). Results: Vascularization (CD31; p = 0.149), proliferation (Mib-1; p = 0.244), and aSMA expression (p = 0.205) did not significantly differ between the two groups, although a trend towards less proliferation and aSMA expression was observed in patients undergoing ALPPS. Concerning apoptosis, caspase-3 staining showed significantly fewer apoptotic cells upon ALPPS (p < 0.0001), but this was not confirmed by TUNEL staining (p = 0.7344). Conclusions: ALPPS does not induce proliferation, apoptosis, or vascularization of CRLM when compared to standard liver resection.

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Metadata last modified: 07 Apr 2022 09:54

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