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Upregulation of hepatic bile acid synthesis via fibroblast growth factor 19 is defective in gallstone disease but functional in overweight individuals

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Renner, Olga ; Harsch, Simone ; Matysik, Silke ; Lütjohann, D. ; Schmitz, Gerd ; Stange, E. F.
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 15 May 2017 13:05


Background: Fibroblast growth factor 19 (FGF19) is an enteric hormone regulating bile acid de novo synthesis by sensing ileal bile acid flux. However, the role of FGF19 in cholelithiasis has not yet been elucidated and therefore is investigated in the present study. Methods: Total mRNA and protein were isolated from ileal biopsies and used for tissue expression analysis. FGF19, ...


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