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Synthese und Anwendung von exo-Methylen-γ-butyrolactonen als potenzielle zytotoxische, carriergebundene Agenzien.

Fürst, Sabrina (2018) Synthese und Anwendung von exo-Methylen-γ-butyrolactonen als potenzielle zytotoxische, carriergebundene Agenzien. PhD, Universität Regensburg.

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Date of publication of this fulltext: 04 Jun 2018 08:32

Abstract (German)

Verschiedene Amin-substituierte α-Methylen-γ-Butyrolactone wurden durch Michael-Addition an die Doppelbindung des Lactons synthetisiert. Als Amine dienten sowohl einfache Amine (Diethylamin, Propylamin), als auch die Seitenkette eines an der Hauptkette Cbz-geschützten Lysins. Das Eliminierungsverhalten der Amine in einer Retro-Michael-Addition unter verschiedenen Bedingungen in wässrigem Medium ...

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Translation of the abstract (English)

Different amine-substituted α-Methylene-γ-Butyrolactones were synthesized by Michael-addition to the double bond of the lactone. As amines served simple amines (diethyl amine, propyl amine) as well as the side chain of a lysine which was cbz-protected at the main chain amino group. The elimination behavior of the amines in a retro-michael-addition under different conditions under aqueous ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:4 June 2018
Referee:Prof. Dr. Oliver Reiser
Date of exam:9 May 2017
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Keywords:exo-Methylen-γ-Butyrolacton, Michael-Addition, Peptidkupplung, Prodrug
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:35690
Owner only: item control page

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