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Cancer Incidence in BRCA1 Mutation Carriers

Thompson, D, Easton, D F and Breast Cancer Linkage Consortium, . (2002) Cancer Incidence in BRCA1 Mutation Carriers. Journal of the National Cancer Institute 94 (18), pp. 1358-1365.

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Other URL: https://academic.oup.com/jnci/article/94/18/1358/2519889/Cancer-Incidence-in-BRCA1-Mutation-Carriers


Background: Germline BRCA1 mutations confer a substantial lifetime risk of breast and ovarian cancer, but whether cancer at other sites is increased is less clear. To evaluate the risks of other cancers in BRCA1 mutation carriers, we conducted a cohort study of 11 847 individuals from 699 families segregating a BRCA1 mutation that were ascertained in 30 centers across Europe and North America. ...


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Item type:Article
Institutions:Medicine > Lehrstuhl für Humangenetik
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Keywords:mutation, cancer, genes, brca1, breast, cervix uteri, ovarian cancer, pancreatic cancer, prostate cancer, cancer risk, brca1 mutation
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:35738
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