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Risk estimation as a decision-making tool for genetic analysis of the breast cancer susceptibility genes. EC Demonstration Project on Familial Breast Cancer

Chang-Claude, J. ; Becher, H. ; Caligo, M. ; Eccles, D. ; Evans, G. ; Haites, N. ; Hodgson, S. ; Moller, P. ; Weber, Bernhard H. F. ; Stoppa-Lyonnet, D.


For genetic counselling of a woman on familial breast cancer, an accurate evaluation of the probability that she carries a germ-line mutation is needed to assist in making decisions about genetic-testing. We used data from eight collaborating centres comprising 618 families (346 breast cancer only, 239 breast or ovarian cancer) recruited as research families or counselled for familial breast ...


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