Genome-wide expression profiling of the retinoschisin-deficient retina in early postnatal mouse development

URN to cite this document:: urn:nbn:de:bvb:355-epub-358309
DOI to cite this document:: 10.5283/epub.35830

Gehrig, A. ; Langmann, T. ; Horling, F. ; Janssen, A. ; Bonin, M. ; Walter, M. ; Poths, S. ; Weber, Bernhard H. F.

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Date of publication of this fulltext: 07 Jul 2017 08:40

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Abstract

purpose. The Rs1h knockout mouse displays retinal features typical for X-linked juvenile retinoschisis (RS). Consequently, this mouse line represents an excellent model to study early molecular events in RS. methods. Whole genome expression profiling using DNA-microarrays was performed on total RNA extracts from retinoschisin-deficient and wild-type murine retinas from postnatal days 7, 9, 11, ...