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Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration

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Baas, D. C. ; Ho, L. ; Tanck, M. W. ; Fritsche, L. G. ; Merriam, J. E. ; van het Slot, R. ; Koeleman, B. P. ; Gorgels, T. G. ; van Duijn, C. M. ; Uitterlinden, A. G. ; de Jong, P. T. ; Hofman, A. ; ten Brink, J. B. ; Vingerling, J. R. ; Klaver, C. C. ; Dean, M. ; Weber, Bernhard H. F. ; et al, .
Date of publication of this fulltext: 07 Jul 2017 09:43


Purpose: Age-related macular degeneration (AMD) is a major cause of blindness in older adults and has a genetically complex background. This study examines the potential association between single nucleotide polymorphisms (SNPs) in the glucose transporter 1 (SLC2A1) gene and AMD. SLC2A1 regulates the bioavailability of glucose in the retinal pigment epithelium (RPE), which might influence ...


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