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Systemic complement activation in age-related macular degeneration

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Scholl, H. P. ; Charbel Issa, P. ; Walier, M. ; Janzer, S. ; Pollok-Kopp, B. ; Börncke, F. ; Fritsche, L. G. ; Chong, N. V. ; Fimmers, R. ; Wienker, T. ; Holz, F. G. ; Weber, Bernhard H. F. ; Oppermann, M.
Date of publication of this fulltext: 07 Jul 2017 11:41


Dysregulation of the alternative pathway (AP) of complement cascade has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly. To further test the hypothesis that defective control of complement activation underlies AMD, parameters of complement activation in blood plasma were determined together with disease-associated ...


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