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In vivo imaging reveals novel aspects of retinal disease progression in Rs1h(-/Y) mice but no therapeutic effect of carbonic anhydrase inhibition

Zhour, A, Bolz, S, Grimm, C, Willmann, G, Schatz, A, Weber, Bernhard H. F. , Zrenner, E and Fischer, M D (2012) In vivo imaging reveals novel aspects of retinal disease progression in Rs1h(-/Y) mice but no therapeutic effect of carbonic anhydrase inhibition. Veterinary Ophthalmology 15 (Suppl2), pp. 123-133.

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Abstract

Purpose  X-linked juvenile retinoschisis (XLRS) is the most common juvenile maculopathy in men and is caused by mutations in the gene encoding retinoschisin (RS1). Evidence in the literature on the therapeutic effect of carboanhydrase inhibitors (CAIs) to treat schisis formation in the retina has remained equivocal. Here, we evaluate the effect of the CAI dorzolamide on the structural and ...

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Item type:Article
Date:2012
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1111/j.1463-5224.2012.01039.xDOI
22672048PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35920
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