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A variant affecting a putative miRNA target site in estrogen receptor (ESR) 1 is associated with breast cancer risk in premenopausal women

Tchatchou, S. ; Jung, A. ; Hemminki, K. ; Sutter, C. ; Wappenschmidt, B. ; Bugert, P. ; Weber, Bernhard H. F. ; Niederacher, D. ; Arnold, N. ; Varon-Mateeva, R. ; Ditsch, N. ; Meindl, A. ; Schmutzler, R. K. ; Bartram, C. R. ; Burwinkel, B.



Abstract

MicroRNAs (miRNAs) negatively regulate expression of target transcripts by hybridization to complementary sites of their messenger RNA targets. Chen et al. have described several putative functional single nucleotide polymorphisms (SNPs) in miRNA target sites. Here, we selected 11 miRNA target site SNPs located in 3′ untranslated regions of genes involved in cancer and breast cancer to analyze ...

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