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A variant affecting a putative miRNA target site in estrogen receptor (ESR) 1 is associated with breast cancer risk in premenopausal women

Tchatchou, S, Jung, A, Hemminki, K, Sutter, C, Wappenschmidt, B, Bugert, P, Weber, Bernhard H. F. , Niederacher, D, Arnold, N, Varon-Mateeva, R, Ditsch, N, Meindl, A, Schmutzler, R K, Bartram, C R and Burwinkel, B (2009) A variant affecting a putative miRNA target site in estrogen receptor (ESR) 1 is associated with breast cancer risk in premenopausal women. Carcinogenesis 30 (1), pp. 59-64.

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Abstract

MicroRNAs (miRNAs) negatively regulate expression of target transcripts by hybridization to complementary sites of their messenger RNA targets. Chen et al. have described several putative functional single nucleotide polymorphisms (SNPs) in miRNA target sites. Here, we selected 11 miRNA target site SNPs located in 3′ untranslated regions of genes involved in cancer and breast cancer to analyze ...

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Item type:Article
Date:2009
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1093/carcin/bgn253DOI
19028706PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35923
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