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Defective complement control of Factor H (Y402H) and FHL-1 in age-related macular degeneration

Skerka, C, Lauer, N, Weinberger, A W A, Keilhauer, C N, Sühnel, J, Smith, R, Schlötzer-Schrehardt, U, Fritsche, L, Heinen, S, Hartmann, A, Weber, Bernhard H. F. and Zipfel, P F (2007) Defective complement control of Factor H (Y402H) and FHL-1 in age-related macular degeneration. Molecular Immunology 44 (13), pp. 3398-3406.

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The common variant in the human complement Factor H gene (CFH), with Tyr402His, is linked to age-related macular degeneration (AMD), a prevalent disorder leading to visual impairment and irreversible blindness in elderly patients. Here we show that the risk variant CFH 402His displays reduced binding to C reactive protein (CRP), heparin and retinal pigment epithelial cells. This reduced binding ...


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Item type:Article
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
17399790PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:35924
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