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Variations in five genes and the severity of age-related macular degeneration: - results from the Muenster aging and retina study

Farwick, A. ; Dasch, B. ; Weber, Bernhard H. F. ; Pauleikhoff, D. ; Stoll, M. ; Hense, H. W.



Abstract

Aims Little is known about the role of genetic variants in the early stages of age-related macular degeneration (AMD). We aimed to investigate how genetic variations within five well-defined genes relate to AMD severity. Methods We analysed SNPs in the genes for complement factor H (CFH), age-related maculopathy susceptibility (ARMS2), HtrA serine peptidase 1 (HtrA1), complement factor B ...

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