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Polymorphisms in BRCA2 resulting in aberrant codon-usage and their analysis on familial breast cancer risk

Yang, R, Chen, B, Hemminki, K, Wappenschmidt, B, Engel, C, Sutter, C, Ditsch, N, Weber, Bernhard H. F. , Niederacher, D, Arnold, N, Meindl, A, Bartram, C, Schmutzler, R and Burwinkel, B (2009) Polymorphisms in BRCA2 resulting in aberrant codon-usage and their analysis on familial breast cancer risk. Breast Cancer Research and Treatment 118 (2), pp. 407-413.

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Abstract

Mutations in BRCA1 and BRCA2 are associated with increased breast cancer risk. While numerous non-synonymous SNPs in BRCA1/2 have been investigated for breast cancer risk, the impact of synonymous SNPs has not been studied so far. Recently, it has been reported that synonymous SNPs leading to an aberration from the preferred codon-usage can have functional effects and consequently be associated ...

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Item type:Article
Date:2009
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1007/s10549-009-0348-7DOI
19229607PubMed ID
Keywords:Breast cancer risk, Case–control study, Codon-usage, BRCA1, BRCA2
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:36001
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