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A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk

Yang, R, Schlehe, B, Hemminki, K, Sutter, C, Bugert, P, Wappenschmidt, B, Volkmann, J, Varon, R, Weber, Bernhard H. F. , Niederacher, D, Arnold, N, Meindl, A, Bartram, C, Schmutzler, R K and Burwinkel, B (2010) A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk. Breast Cancer Research and Treatment 121 (3), pp. 693-702.

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Abstract

MicroRNAs (miRNAs) regulate pathways involved in cell differentiation, proliferation, development, and apoptosis by degradation of target mRNAs and/or repression of their translation. Although the single nucleotide polymorphisms (SNPs) in miRNAs target sites have been studied, the effects of SNPs in miRNAs are largely unknown. In our study, we first systematically sequenced miRNA genes reported ...

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Item type:Article
Date:2010
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1007/s10549-009-0633-5DOI
Keywords:Breast cancer risk, MicroRNA, SNP, Case–control study
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:36002
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