TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals

URN to cite this document:: urn:nbn:de:bvb:355-epub-360189
DOI to cite this document:: 10.5283/epub.36018

Stöhr, H. ; Heisig, J. B. ; Benz, P. M. ; Schöberl, S. ; Milenkovic, V. M. ; Strauss, O. ; Aartsen, W. ; Wijnholds, J.

; Weber, Bernhard H. F.

; Schulz, H. L.

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Date of publication of this fulltext: 04 Aug 2017 08:07

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Abstract

Photoreceptor ribbon synapses release glutamate in response to graded changes in membrane potential evoked by vast, logarithmically scalable light intensities. Neurotransmitter release is modulated by intracellular calcium levels. Large Ca2+-dependent chloride currents are important regulators of synaptic transmission from photoreceptors to second-order neurons; the molecular basis underlying ...