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TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals

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Stöhr, H. ; Heisig, J. B. ; Benz, P. M. ; Schöberl, S. ; Milenkovic, V. M. ; Strauss, O. ; Aartsen, W. . ; Wijnholds, J. ; Weber, Bernhard H. F. ; Schulz, H. L.
Date of publication of this fulltext: 04 Aug 2017 08:07


Photoreceptor ribbon synapses release glutamate in response to graded changes in membrane potential evoked by vast, logarithmically scalable light intensities. Neurotransmitter release is modulated by intracellular calcium levels. Large Ca2+-dependent chloride currents are important regulators of synaptic transmission from photoreceptors to second-order neurons; the molecular basis underlying ...


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