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S156C mutation in tissue inhibitor of metalloproteinases-3 induces increased angiogenesis

Qi, J H, Dai, G, Luthert, P, Chaurasia, S, Hollyfield, J, Weber, Bernhard H. F. , Stöhr, H and Anand-Apte, B (2009) S156C mutation in tissue inhibitor of metalloproteinases-3 induces increased angiogenesis. The Journal of Biological Chemistry 284, pp. 19927-19936.

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Date of publication of this fulltext: 04 Aug 2017 08:10

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Other URL: http://www.jbc.org/content/284/30/19927.long


Abstract

Tissue Inhibitor of metalloproteinases-3 (TIMP-3) is a potent matrix-bound angiogenesis inhibitor. Mutations in TIMP-3 cause Sorsby Fundus Dystrophy, a dominant inherited, early onset macular degenerative disease, with choroidal neovascularization causing a loss of vision in the majority of patients. Here we report that expression of S156C TIMP-3 mutation in endothelial cells results in an ...

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Item type:Article
Date:2009
Institutions:Medicine > Lehrstuhl für Humangenetik
Identification Number:
ValueType
10.1074/jbc.M109.013763DOI
19478078PubMed ID
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:36019
Owner only: item control page

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