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S156C mutation in tissue inhibitor of metalloproteinases-3 induces increased angiogenesis

URN to cite this document:
urn:nbn:de:bvb:355-epub-360195
DOI to cite this document:
10.5283/epub.36019
Qi, J. H. ; Dai, G. ; Luthert, P. ; Chaurasia, S. ; Hollyfield, J. ; Weber, Bernhard H. F. ; Stöhr, H. ; Anand-Apte, B.
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Date of publication of this fulltext: 04 Aug 2017 08:10


Abstract

Tissue Inhibitor of metalloproteinases-3 (TIMP-3) is a potent matrix-bound angiogenesis inhibitor. Mutations in TIMP-3 cause Sorsby Fundus Dystrophy, a dominant inherited, early onset macular degenerative disease, with choroidal neovascularization causing a loss of vision in the majority of patients. Here we report that expression of S156C TIMP-3 mutation in endothelial cells results in an ...

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