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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-360195
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.36019
Zusammenfassung
Tissue Inhibitor of metalloproteinases-3 (TIMP-3) is a potent matrix-bound angiogenesis inhibitor. Mutations in TIMP-3 cause Sorsby Fundus Dystrophy, a dominant inherited, early onset macular degenerative disease, with choroidal neovascularization causing a loss of vision in the majority of patients. Here we report that expression of S156C TIMP-3 mutation in endothelial cells results in an ...
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