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Nuclear receptor coregulator SNP discovery and impact on breast cancer risk

Hartmaier, R. J. ; Tchatchou, S. ; Richter, A. S. ; Wang, J. ; McGuire, S. E. ; Skaar, T. C. ; Rae, J. M. ; Hemminki, K. ; Sutter, C. ; Ditsch, N. ; Bugert, P. ; Weber, Bernhard H. F. ; Niederacher, D. ; Arnold, N. ; Varon-Mateeva, R. ; Wappenschmidt, B. ; Schmutzler, R. K. ; Meindl, A. ; Bartram, C. R. ; Burwinkel, B. ; Oesterreich, S.



Abstract

Background Coregulator proteins are "master regulators", directing transcriptional and posttranscriptional regulation of many target genes, and are critical in many normal physiological processes, but also in hormone driven diseases, such as breast cancer. Little is known on how genetic changes in these genes impact disease development and progression. Thus, we set out to identify novel single ...

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