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Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people

McKay, G. J. ; Silvestri, G. ; Chakravarthy, U. ; Dasari, S. ; Fritsche, L. G. ; Weber, Bernhard H. F. ; et al, .


Variation in the apolipoprotein E gene (APOE) has been reported to be associated with longevity in humans. The authors assessed the allelic distribution of APOE isoforms ε2, ε3, and ε4 among 10,623 participants from 15 case-control and cohort studies of age-related macular degeneration (AMD) in populations of European ancestry (study dates ranged from 1990 to 2009). The authors included only the ...


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