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Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells

Seebauer, Caroline Theresa (2017) Peritoneal carcinomatosis of colorectal cancer is characterized by structural and functional reorganization of the tumor microenvironment inducing senescence and proliferation arrest in cancer cells. PhD, Universität Regensburg.

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Date of publication of this fulltext: 24 Jul 2017 06:31

Abstract (English)

Peritoneal carcinomatosis (PC) is a terminal evolution from primary colorectal cancer (pCRC) associated with poor patient survival. Impact of the immune cell infiltrate on PC pathogenesis is unknown. Therefore, we characterized the immunological tumor microenvironment regarding proliferation, senescence and neovascularization. Formalin-fixed and paraffin-embedded (FFPE) tissue of PC and pCRC was ...

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Translation of the abstract (German)

Peritonealkarzinose ist eine Metastasierungsform des primären kolorektalen Karzinoms, die mit kurzer Lebenserwartung der Patienten verknüpft ist. Bei Patienten mit primärem kolorektalen Karzinom haben die Immunzellen der Tumorumgebung Auswirkungen auf Tumorentstehung, -progression, -ausbreitung und den klinischen Outcome. Der Einfluss, den das umgebende Tumormikromilieu auf die Pathogenese der ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:24 July 2017
Referee:Prof. Dr. Hans J. Schlitt
Date of exam:13 July 2017
Institutions:Medicine > Lehrstuhl für Chirurgie
Keywords:peritoneal carcinomatosis, tumor milieu, TH1, TH17, senescence, proliferation
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:36032
Owner only: item control page

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