Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load

URN to cite this document:: urn:nbn:de:bvb:355-epub-360500
DOI to cite this document:: 10.5283/epub.36050

Dex, Sarah ; Alberton, Paolo ; Willkomm, Lena ; Söllradl, Thomas ; Bago, Sandra ; Milz, Stefan ; Shakibaei, Mehdi ; Ignatius, Anita

; Bloch, Wilhelm ; Clausen-Schaumann, Hauke

; Shukunami, Chisa ; Schieker, Matthias

; Docheva, Denitsa

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Date of publication of this fulltext: 04 Sep 2017 09:10

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Abstract

Tendons are dense connective tissues that attach muscles to bone with an indispensable role in locomotion because of their intrinsic properties of storing and releasing muscle-generated elastic energy. Tenomodulin (Tnmd) is a well-accepted gene marker for the mature tendon/ligament lineage and its loss-of -function in mice leads to a phenotype with distinct signs of premature aging on tissue and ...