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Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load

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Dex, Sarah ; Alberton, Paolo ; Willkomm, Lena ; Söllradl, Thomas ; Bago, Sandra ; Milz, Stefan ; Shakibaei, Mehdi ; Ignatius, Anita ; Bloch, Wilhelm ; Clausen-Schaumann, Hauke ; Shukunami, Chisa ; Schieker, Matthias ; Docheva, Denitsa
Date of publication of this fulltext: 04 Sep 2017 09:10


Tendons are dense connective tissues that attach muscles to bone with an indispensable role in locomotion because of their intrinsic properties of storing and releasing muscle-generated elastic energy. Tenomodulin (Tnmd) is a well-accepted gene marker for the mature tendon/ligament lineage and its loss-of -function in mice leads to a phenotype with distinct signs of premature aging on tissue and ...


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