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Dual antitumour effect of 5-azacytidine by inducing a breakdown of resistance-mediating factors and epigenetic modulation

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Venturelli, S. ; Berger, A. ; Weiland, T. ; Weiss, Thomas S.
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 08 Aug 2017 09:42


Background: The cytokine tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown promising anticancer activity in early clinical settings by selectively inducing apoptosis in different tumour types. However, some tumour entities such as hepatocellular carcinoma (HCC) display an inherent resistance to TRAIL. A huge effort has been made to unravel strategies for a clinically ...


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