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Amelioration of portal hypertension and the hyperdynamic circulatory syndrome in cirrhotic rats by neuropeptide Y via pronounced splanchnic vasoaction

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Moleda, Lukas ; Trebicka, J. ; Dietrich, Peter ; Gäbele, Erwin ; Hellerbrand, Claus ; Straub, Rainer H. ; Sauerbruch, T. ; Schölmerich, Jürgen ; Wiest, Reiner
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 31 Aug 2017 13:20


Background: Splanchnic vasodilation triggers the development of the hyperdynamic circulatory syndrome in portal hypertension. Neuropeptide Y (NPY), a sympathetic co-transmitter of norepinephrine, improves contractility in mesenteric arteries of pre-hepatic portal hypertensive rats. Therefore, we investigated the effect of NPY on mesenteric arterial contractility in vitro and in vivo in cirrhotic ...


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