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Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice

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DOI to cite this document:
Jauch, Dominik ; Martin, Maria ; Schiechl, Gabriela ; Kesselring, Rebecca ; Schlitt, Hans J. ; Geissler, Edward K. ; Fichtner-Feigl, Stefan
License: Allianz- bzw. Nationallizenz
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Date of publication of this fulltext: 04 Sep 2017 09:23


Background and aims: Colitis-associated tumorigenesis is a balance between proliferation of tumour cells and tumour immunosurveillance. The role of T-helper-cell-derived cytokines in tumour growth is not fully understood. In this study the authors investigated the influence of interleukin (IL) 21 on intestinal tumorigenesis. Methods: Chronic colitis was induced in IL-21−/− and littermate control ...


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