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Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice

URN to cite this document:
urn:nbn:de:bvb:355-epub-361371
DOI to cite this document:
10.5283/epub.36137
Jauch, Dominik ; Martin, Maria ; Schiechl, Gabriela ; Kesselring, Rebecca ; Schlitt, Hans J. ; Geissler, Edward K. ; Fichtner-Feigl, Stefan
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Date of publication of this fulltext: 04 Sep 2017 09:23



Abstract

Background and aims Colitis-associated tumorigenesis is a balance between proliferation of tumour cells and tumour immunosurveillance. The role of T-helper-cell-derived cytokines in tumour growth is not fully understood. In this study the authors investigated the influence of interleukin (IL) 21 on intestinal tumorigenesis. Methods Chronic colitis was induced in IL-21(-/-) and littermate control ...

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