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Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice

Jauch, Dominik, Martin, Maria, Schiechl, Gabriela, Kesselring, Rebecca, Schlitt, Hans J. , Geissler, Edward K. and Fichtner-Feigl, Stefan (2011) Interleukin 21 controls tumour growth and tumour immunosurveillance in colitis-associated tumorigenesis in mice. Gut 60, pp. 1678-1686.

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Abstract

Background and aims: Colitis-associated tumorigenesis is a balance between proliferation of tumour cells and tumour immunosurveillance. The role of T-helper-cell-derived cytokines in tumour growth is not fully understood. In this study the authors investigated the influence of interleukin (IL) 21 on intestinal tumorigenesis. Methods: Chronic colitis was induced in IL-21−/− and littermate control ...

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Item type:Article
Date:2011
Institutions:Medicine > Lehrstuhl für Chirurgie
Identification Number:
ValueType
10.1136/gutjnl-2011-300612DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:36137
Owner only: item control page

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